About a year ago a friend from London showed me a clip from the Ukelele Orchestra and I was hooked from the first note. I can't begin to properly describe their music - it's really something you have to see/hear for yourself. This song, "Fly Me Off the Handel," is a particular favorite of mine.
There are many others on Youtube that are just as good. If you liked this one, I also recommend "Killing Me Softly" and "Rawhide."
Enjoy and have a great weekend.